Hydroxypinacolone retinoate (granactive retinoid)
On the label: Hydroxypinacolone Retinoate · Active
What it is
An ester of retinoic acid sold as a gentler retinoid; usually listed with a carrier like dimethyl isosorbide.
Actives: Actives are the ingredients a product is built around: acids, retinoids, vitamins and the like.
Wikidata: Chemical compound. Q27284891 →
In the research
18 PubMed papers mention it with skin, cosmetics or hair; the three most recent:
- Multi-Omics Reveals That Hydroxypinacolone Retinoate Alleviates UV-Induced Skin Aging via the p38/MMP9/Collagen Axis · Clinical, cosmetic and investigational dermatology, 2026
- A Nanoliposome Platform Co-Delivery of Hydroxypinacolone Retinoate and Carnosine for Enhanced Epidermal/Dermal Delivery and Multi-Functional Anti-Aging Efficacy · Pharmaceutics, 2026
- Preparation and Characterization of Zein/Salecan Nanocomposite Particles for Enhanced Stability and Bioactivity of Lipophilic Retinoids · Chemistry, an Asian journal, 2026
A paper is a paper, not a verdict: titles are listed so you can read them, and a study on cells or mice says little about a cream on a face.
Other actives
Dew & Balm describes ingredients from the public record and makes no claim about what a product will do for you. Statements about dietary supplements have not been evaluated by the FDA. If a product causes a reaction, stop using it; a reaction that spreads or affects breathing is a call to a doctor or 911.