Acetyl hexapeptide-8 (argireline)
On the label: Acetyl Hexapeptide-8 · Active
What it is
A six-amino-acid peptide marketed for expression lines; works on the surface only, whatever the marketing says about muscles.
Actives: Actives are the ingredients a product is built around: acids, retinoids, vitamins and the like.
In the research
22 PubMed papers mention it with skin, cosmetics or hair; the three most recent:
- Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking · International journal of cosmetic science, 2026
- Effects of Botulinum Toxin Type A and Argireline on Dermal Collagen Remodeling and Skin Biology in a Flap Model · Aesthetic plastic surgery, 2026
- Ex Vivo Evaluation of Skin Permeability Enhancement Using TargetCool in Human-Derived Skin Tissue Models · The Journal of craniofacial surgery, 2026
A paper is a paper, not a verdict: titles are listed so you can read them, and a study on cells or mice says little about a cream on a face.
Other actives
Dew & Balm describes ingredients from the public record and makes no claim about what a product will do for you. Statements about dietary supplements have not been evaluated by the FDA. If a product causes a reaction, stop using it; a reaction that spreads or affects breathing is a call to a doctor or 911.